Therefore, it is not surprising to find that VV-miR-34a has the ability to assist the release of cytochrome c in combination of VV-Smac and VV-miR-34a and synergistically increases the antiproliferation of VV-Smac on MM cell line in vitro or in vivo, which may provide a promising strategy for treatment of MM. The gene discussed is CYCS; the disease is Miyoshi myopathy.