Being positive for both AFP and serum CA19-9 were more common in the CHC group (29.4% [10 of 34]) than in the pure HCC group (2.0% [1 of 50], P < 0.001) and the pure ICC group (10.0% [5 of 50], P = 0.023). The gene discussed is AFP; the disease is hepatocellular carcinoma.