We assessed how selective disruption of BDNF from activity-dependent promoter IV (Bdnf-e4 mice)33 impacts arousal, sensory processing, fear regulation and sleep; phenotypes that are associated with altered brain physiology in PTSD.2, 34, 35, 36 Using a combination of behavior testing and in vivo electrophysiology, we demonstrate a number of phenotypes relevant to PTSD including sensory hyper-reactivity and impaired neural correlates of sensory information processing as measured with event-related potential (ERP) recordings in Bdnf-e4 mice. Here, BDNF is linked to post-traumatic stress disorder.