BDNF and post-traumatic stress disorder: Specifically, induction of LTP in the HPC–PFC pathway was reduced relative to nonstressed mice, and there was less enhancement in post-LTP HPC–PFC theta phase synchrony.74 As carriers of the BDNF Val66Met mutation are at increased risk for PTSD development when exposed to multiple stressful life events,30, 31 it would be interesting to explore the relationship of carrier status to theta activity and memory recall in individuals with PTSD.