AKT1 and acute lymphoblastic leukemia: Unlike PI3K/AKT/mTOR pathway inhibitors which can re-sensitize T-ALL cells to GC treatment by upregulation of pro-apoptotic proteins of Bim and Bax [37], CPX mainly downregulated the expression of anti-apoptosis proteins of Bcl-2, Mcl-1, and Bcl-xL.