Survival analysis of MMP-2 haplotypes (Fig 3) revealed a similar profile as that observed for individual polymorphisms, as Caucasian-Brazilians homozygous for the haplotype composed of the major alleles (-1575G/-1059G/-790T) had a better HF-related survival rate than those who carried at least 1 copy of either -1575A/-1059G/-790G, -1575G/-1059G/-790G, or -1575G/-1059A/-790T haplotypes (Fig 3B). The gene discussed is MMP2; the disease is hydrops fetalis.