A study carried out in Pakistan, a country where Dengue is endemic, in the year 2011, with a sample of 640 patients to report the clinical parameters and pattern of Hemorrhagic complications, reported the presence of abdominal pain, purpuric rash, ascites, very low platelet count, significantly raised ALT and evidence of coagulopathy in the form of prolonged prothrombin time and activated partial thromboplastin time, have high predictability value for the development of DHF[15]. Here, F2 is linked to Dengue hemorrhagic fever.