RIPK3 aggregation and activation have been recently shown to activate the inflammasome under certain conditions,20,31 and inflammasome activation has been implicated in the AMD pathogenesis.32–35 Inflammasome activation could lead to the induction of pyroptosis, a type of cell death that depends on caspase-1 activation. This evidence concerns the gene CASP1 and age-related macular degeneration.