EGFR and malignant glioma: High-grade glioma (HGG) is the most common neoplasm of the brain and is almost universally lethal.1 One of the most frequently altered genes in HGG is the epidermal growth factor receptor (EGFR) gene.2 The most common alteration is amplification of wild-type (wt) EGFR, which is observed in around half of all HGG tumors.