Vorinostat or Trichostatin A treatment was found to induce EMT through upregulation of ZEB1, ZEB2, SNAI1 and SNAI2 expression, with associated increased expression of mesenchymal markers, N-cadherin and vimentin, in prostate cancer cells.34 Similar results were obtained in human nasopharyngeal carcinoma cells (CNE2), colon cancer cells (LoVo) and liver carcinoma cells (HepG2). This evidence concerns the gene CDH2 and hepatocellular carcinoma.