ZEB1 and hepatocellular carcinoma: Vorinostat or Trichostatin A treatment was found to induce EMT through upregulation of ZEB1, ZEB2, SNAI1 and SNAI2 expression, with associated increased expression of mesenchymal markers, N-cadherin and vimentin, in prostate cancer cells.34 Similar results were obtained in human nasopharyngeal carcinoma cells (CNE2), colon cancer cells (LoVo) and liver carcinoma cells (HepG2).