TGFB1 and cancer: These cancer cells demonstrated increased SNAI1 expression and metastasis, coupled with a fibroblast-like morphology of mesenchymal cells, after Vorinostat or Sodium butyrate (NaB) treatment.35 On the contrary, treatment with either Vorinostat or Trichostatin A, squamous cell carcinoma of the head and neck (SCCHN) cells, induced E-cadherin expression and suppressed TGFβ expression, an indication of EMT inhibition.36 Recently, several epigenetic modifiers have indeed been reported to reverse the aggressiveness associated with EMT in solid tumors.37–40