We have previously shown that in prostate cancer cell lines derived from advanced metastatic cancers, miR-31 is downregulated to contribute to the resistance to chemotherapy-induced apoptosis.22 Here, we demonstrated that mocetinostat activates the expression of miR-31, which in turn decreases the antiapoptotic protein E2F6. The gene discussed is E2F6; the disease is prostate carcinoma.