The extrinsic signaling involves transmembrane receptor-mediated interaction and among them FasL/FasR and TNF-α/TNFR1 are the best characterized.1 FasL is constitutively expressed in the normal eye and has been shown to have an essential role in maintaining the immune-privileged environment by inducing the apoptosis in infiltrating inflammatory cells and evoking protection against ocular viral infections.48 In a recent study by Sugi et al.49 demonstrates that FasL is essential in promoting the resolution of inflammation and exerts protective effects in bacterial endophthalmitis. The gene discussed is TNFRSF1A; the disease is viral eye infection.