A significant increase in the cleavage of caspase-3 along with DNA fragmentation is consistently observed among various retinal diseases, including cytomegalovirus retinitis.54,55 An earlier study by Whiston et al.56 also showed the involvement of caspase-3 in S. aureus-induced apoptosis and its inhibition by αβ crystalline protein. This evidence concerns the gene CASP3 and cytomegalovirus retinitis.