The extrinsic signaling involves transmembrane receptor-mediated interaction and among them FasL/FasR and TNF-α/TNFR1 are the best characterized.1 FasL is constitutively expressed in the normal eye and has been shown to have an essential role in maintaining the immune-privileged environment by inducing the apoptosis in infiltrating inflammatory cells and evoking protection against ocular viral infections.48 In a recent study by Sugi et al.49 demonstrates that FasL is essential in promoting the resolution of inflammation and exerts protective effects in bacterial endophthalmitis. Here, NRP1 is linked to viral eye infection.