To this end, they employed trehalose-6, 6ʹ-dibehenate (TDB), a synthetic glycolipid ligand for Mincle.10 Although the administration method of this insoluble lipid was not specified, the authors reported that in vivo injection of TDB promoted PDA progression, which is a striking contrast to the recent clinical studies demonstrating its adjuvant effects.11 In line with their hypothesis, Mincle deficiency resulted in reduced tumor size and is likely to improve survival compared with Mincle-sufficient condition. Here, CLEC4E is linked to neoplasm.