Myeloid-derived suppressor cells (MDSC), ‘M2-type’ tumor-associated macrophages (TAM) and regulatory T cells are proposed to promote tumor development mainly via inhibition of T cells with anti-tumor activity, whereas tumor-infiltrating IFN-γ-producing αβ T cells blocked the development of PDA.7 RIP3 deficiency in KRASG12D mice reduced frequencies of suppressive immune cells, whereas peritumoral T cells significantly increased. The gene discussed is IFNG; the disease is neoplasm.