CLEC4E and obesity due to melanocortin 4 receptor deficiency: Mincle is an ITAM-coupled activating C-type lectin receptor, which is induced upon various stimuli and stresses on myeloid cells and recognizes dead cells.8 More recently, Mincle was shown to be involved in obesity-induced adipose tissue fibrosis presumably via the recognition of endogenous ligand(s).9 The authors detected Mincle expression in PDA-infiltrating myeloid cells.