RRM2 and colorectal adenoma: To further investigate the essential role of RRM2 in CRC, its expression in colorectal adenomas and adjacent normal mucosa of CRC patients was analyzed from a published microarray dataset (GSE867110) obtained from the NCBI Gene Expression Omnibus (GEO) database.11 Adenomatous polyps are believed to be the precancerous lesions of CRC.12 As shown in Figure 1b, the level of RRM2 was higher in adenomas.