The regulatory-associated protein of mTOR (raptor) is composed of three evolutionarily conserved domains: a raptor N-terminal (N-term) conserved domain (also called RNC), three HEAT repeats and seven WD repeats, which are protein interaction domains mediating the raptor–mTOR interaction.14 This interaction has been previously shown to be weakened after curcumin or high-dose rapamycin treatments.34,36 For this reason, we next investigated the effect of curcumin or rapamycin on lymphoma cell lines. The gene discussed is RPTOR; the disease is lymphoma.