NFKB1 and B-cell chronic lymphocytic leukemia: As several TNF family members can induce NF-κB,29 we investigated if APRIL is able to induce NF-κB activation by performing an NF-κB DNA-binding enzyme-linked immunosorbent assay and found that, as expected, 3T40 cells induced both the canonical (p65) and non-canonical (p52) pathway in CLL cells.