CASP1 and cancer: A number of studies have investigated NLRP3 in cancer, with reports of both anti-carcinogenic and pro-tumorigenic roles for NLRP3.37 For example, in a recent report, murine Nlrp3 deficiency increased metastatic foci in the liver in a model of colorectal cancer metastasis.38 Another report linked NLRP3 expression and caspase-1 activation to glucocorticoid resistance in leukemia cells,39 suggesting that blocking NLRP3 and caspase-1 activation in the latter context would be beneficial.