NLRP3 and infection: IL-1 blockade in patients does cause a small increase in the incidence of infections.35 However, the redundancy within and between IL-1-producing inflammasomes and other PRR pathways suggests NLRP3 inhibition will likely not generally predispose to infection, although it could increase risk to a small number of specific infections for which NLRP3 plays a non-redundant role in pathogen control, such as Candida albicans.