IL4R and osteosarcoma: This was supported by upregulation of NFKB1A and NFKB1Z, which inhibit NF-κB activity and suppress proangiogenic molecules such as MMP9,21,22 and are associated with osteosarcoma.23 Likewise, other immune-related genes, CXCL8, IL4R and IL10, were upregulated to promote cytokine responses and suppress tumorigenesis.