SETDB1 and melanoma: Among the different HMTs, SETDB1 has been of increasing interest due to its involvement in melanoma, where it is located in a recurrently amplified chromosome fragment.11 SETDB1 amplification has been also described in lung tumors.12 Regina et al. 9 demonstrated that SETB1 is also overexpressed in different breast cancer cell lines and in primary tumors.