TNFSF10 and cancer: It has been reported that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), staurosporine, etoposide and ultraviolet irradiation induce the pan-nuclear γH2AX response associated with apoptosis in human cancer cells,22 mouse fibroblasts, Chinese hamster ovary cells, human fibroblasts23–25 and resting human T cells.26 The pan-nuclear γH2AX response can be caused by replication-mediated DSBs in cancer cells treated with camptothecin,27 indenoisoquinolines28 or gemcitabine,29 which are not related to apoptotic DNA fragmentation.