Similarly, additional ectopically expressed ORs, such as OR2AT4 in CML, AML and in skin, or the OR1A2 in the hepatocarcinoma cell line Huh7, were reported to involve the AC-mediated signaling pathway.7,10,11 However, it is reported that ORs can use different mechanisms, such as activating Src kinases or using a Gq-, Gi-mediated pathway.3,32–34. Here, OR2AT4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.