OR51B5 and chronic myelogenous leukemia, BCR-ABL1 positive: An increase in intracellular Ca2+ leads to alternations in cellular functions either by an indirect mechanism or via inhibition of MAPK phosphorylation.7,10,11,28–31 The characterization of the OR51B5-mediated signaling pathway showed that the receptor activates an AC-mediated pathway in both AML and CML and further activates downstream L-type and T-type calcium channels.