CASP2 and Glucose intolerance: Previously, we observed reduced fed and fasted blood glucose levels in aged male Casp2−/− mice and protection from age-induced glucose intolerance that was observed in WT mice following glucose tolerance testing.10 Although aged Casp2−/− mice have increased oxidative damage, studies have shown that increased ROS in mice can result in enhanced insulin sensitivity.18 To determine if this was a reason for improved glucose tolerance in aged male Casp2−/− mice, insulin tolerance testing was performed following a 6-h fast.