BAG3 and neoplasm: BAG3 positivity of neo-vessels in granulation tissues is in agreement with the reported expression of BAG3 in tumor neoangiogenetic vessels.7 Importantly, this finding confirms the link between BAG3 expression and neoangiogenesis in a different pathophysiological context, probably in connection with BAG3 role in regulating ERK-DUSP6 interaction and cell cycle progression.7 In addition, BAG3 expression was observed not only in neo-endothelial but also in stromal cells.