AMPK, under nutritional stress, maintains energy balance by minimizing energy expense and accelerating ATP generation to restore its level in favor of cell survival.30 Role of AMPK in cancer is not very clear as it has been reported to exhibit both tumor-suppressing as well as tumor-promoting function.31–33 Considering the heterogeneity and physiological stress in tumor microenvironment, it is inevitable for cancer cells to evolve a mechanism to overcome/adapt to various stresses to maintain survival. This evidence concerns the gene PRKAA1 and neoplasm.