The mitogen-activated protein kinase such as extracellular signal-regulated kinase (ERK) and p38 are involved in cell growth, death and breast cancer chemoresistance.30 Therefore, Dox and histamine effects on phospho-ERK1/2 (p-ERK1/2) and phospho-p38 (p-p38) were assayed by western blot. The gene discussed is MAPK3; the disease is breast cancer.