PDE6B and retinitis pigmentosa 1: Rd10 mice are an animal model of RP caused by a missense mutation in the Pde6β gene.16 Mutations in this gene have been found in patients with autosomal recessive RP.17Rd10 mice develop progressive rod degeneration beginning around postnatal day 18 (P18), and only a slight proportion of rod cells remains at P28; the number of cone cells gradually decreases thereafter.