Although many studies have revealed that TF-FVII-PAR2 signaling can initiate cell signal transduction in the pathogenesis of cancers and promotes cell migration and invasion,14,15,21 the detailed signaling transduction mechanisms responsible for the TF-FVII-PAR2 in HCC are not fully understood. The gene discussed is F2RL1; the disease is hepatocellular carcinoma.