MCL1 and breast carcinoma: Analysis of somatic copy-number alterations in multiple cancer types demonstrated amplification of the MCL1 locus in 10.9% of cancers, with a higher prevalence in lung and breast cancer.28 Knockdown of MCL1 in MCL1-amplified cell lines resulted in reduced proliferation and survival, further implying that MCL-1 could be an interesting target in lung cancer.