Combining TKIs with direct inducers of apoptosis such as BH3 mimetic compounds has been proposed for the treatment of lung cancer.26 Cragg et al.27 showed that induction of BIM by EGFR TKI in EGFR-mutated NSCLC was necessary to induce cell death, and that combination of EGFR TKI with the BH3 mimetic ABT-737 potentiated cell death. This evidence concerns the gene EGFR and lung carcinoma.