ING1b is the best-studied member of ING family and is predominantly found in Sin3A HDAC1- and HDAC2-containing complexes,3 where it mediates recruitment of these complexes to chromatin targets.4 Recently, ING1b was also shown to function in gene-specific DNA demethylation,5 and to regulate gene expression by modulating microRNA biogenesis.6 Consistent with their designation as tumour suppressors, a large number of clinical studies have reported complete or partial loss of ING1b expression in different type of tumours.7–9. The gene discussed is HDAC2; the disease is neoplasm.