It has been reported that knockdown of anti-apoptotic Bcl-2 proteins directly inhibits the migration and invasion of the CRC cells HT29 and SW480, independent of their cell death induction or effects on proliferation.39 However, our results show that overexpression of Bcl-2 in HCT116 MUT cells impairs gap closure in a wound-healing assay (Figure 7b). This evidence concerns the gene BCL2 and colorectal carcinoma.