GSN and prostate cancer: Ke et al. 29 reported that Bcl-2 enhances actin polymerization and proposed a mechanism for the enhanced actin polymerization by Bcl-2: Bcl-2 expression may regulate the gelsolin-mediated activity of F-actin severing.31 Interestingly, it was reported that overexpression of Bcl-2 results in cells acquiring a rounded shape and increased actin expression in the prostate cancer cell line PC12.35 This agrees with our finding that WT-p110α HCT116 cells possess high levels of Bcl-2 and display more circular cell morphology compared with MUT cells.