BCL2 and neoplasm: Furthermore, several reports have shown that loss of Bcl-2 expression correlates with tumor recurrence in CRC.37 A high level of Bcl-2 is also predictive of relapse-free survival of stage II CRC.38 These findings suggest that the H1047R mutation enhanced liver metastasis of CRC7 may be related to the low level of Bcl-2 expression.