Calculation of the HOMA index of degree of insulin resistance (HOMA-IR) demonstrated decreased insulin sensitivity in transgenic DNHNF-1αbmf+/+ mice (13.2±3.2) compared with WTbmf+/+ (7.3±1.5), not rescued by deletion of bmf (DNHNF-1αbmf−/−P=1.0, WTbmf−/−P=0.7). This evidence concerns the gene BMF and Insulin resistance.