Utilizing an established transgenic mouse model of HNF1α-MODY with a specific beta-cell-targeted DNHNF-1α mutation shown to result in glucose intolerance and overt diabetes,11,12bmf expression was knocked out to examine the effect of loss-of-function of this BH3-only protein on disease pathology and progression, and further elucidate the role of Bmf in mediating DNHNF-1α-induced apoptosis. Here, BMF is linked to diabetes mellitus.