In support of this notion, Wwox heterozygous mice develop higher incidence of spontaneous tumors.9 Furthermore, McAvoy et al5 reported that there is no relationship between alteration of a given CFS and expression of its associated gene product in a given cancer, suggesting that these alterations are not merely responsible for dysregulation of WWOX protein expression. Here, WWOX is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.