PPARG and central nervous system cancer: Although hypoxic stress-induced HIF-1α negatively regulates PPARγ during adipocytic differentiation,8 pathologic stress-induced PPARγ upregulation involves HIF-1α activation in cardiomyocytes.9 Besides, PPARγ agonist pioglitazone has been reported to inhibit glioma survival.10 Given the importance of HIF-1α in glioma biology, and involvement of PPARγ in CIDEA expression; we investigated the (i) role of HIF-1α and PPARγ in CIDEA expression and (ii) the role of CIDEA in glioma cell survival.