Among the three members of cell death-inducing DFFA-like effector (CIDE) protein family, the role of CIDEA in lipid metabolism is documented.1 CIDEA is also known to induce apoptosis.2 Though a low expression level of CIDEA in different malignancies including glioblastoma multiforme (GBM) is documented,3 the mechanisms of its regulation and role in tumor progression remain unexplored. This evidence concerns the gene CIDEA and glioblastoma.