AXIN1 and malignant colon neoplasm: This is consistent with the finding that phosphorylation of β-catenin at Ser33, Ser37 or Thr41 can occur in the absence of phosphorylation at Ser45 in colon cancer cells.48 The small-molecule JW74, which works through stabilization of Axin, was also reported attenuating Wnt signaling in HCT116 cells.20