First, Noxa and SARM are reported to be proapoptotic,11,13 and, second, SAG (antiapoptotic) displays reciprocal levels of expression in primary macrophages during infection.11 These findings prompted us to hypothesize that in liver cancer, SAG probably downregulates SARM and Noxa, thus promoting cancer cell survival. The gene discussed is PMAIP1; the disease is liver cancer.