HOXB4 and cancer: First, it is suggested that β-Catenin is able to block differentiation by modulating differentiation- and proliferation-specific genes.52 Exemplarily, β-Catenin repressed C/EBPα expression in adipogenesis.53 In addition, the regulators of hematopoietic stem cell self-renewal, Hoxb4 and Bmi1, are target genes of the Wnt/β-Catenin signaling.54 Second, it was reported in recent literature that β-Catenin inhibits autophagy in several cancer cells.