Interestingly, E-Cadherin expression is often epigenetically silenced by aberrant hypermethylation, leading to enhanced migration in AML, and is correlated with poor prognosis.57 In our study, we confirmed the importance of E-Cadherin for the inhibition of tumor progression as downmodulation of E-Cadherin efficiently attenuated LecB-induced differentiation (Figure 6a). This evidence concerns the gene CDH1 and acute myeloid leukemia.