Our data are consistent with a recent report showing that mFUS-positive SGs accumulate when autophagy is inhibited, but they disperse when autophagy is activated.19 Similarly, co-infection of adenoviral constructs encoding shRNA for proteins associated with the proteasome (PSMC1), autophagy (ATG5) and endosome (VPS24), with TDP-43 or FUS, enhances cytoplasmic TDP-43 or FUS aggregate formation in facial motor neurons. The gene discussed is TARDBP; the disease is coinfection.