SGs are degraded by autophagy involving ubiquitin-selective chaperone valosin-containing protein, which is also mutated in familial ALS.16 Cytosolic mFUS is localised to SGs and FUS-positive cytosolic inclusions associate with SG proteins, including PABP, in brains of patients with ALS.17,18 Furthermore, mFUS-positive SGs co-localises with LC3-positive autophagosomes19 and autophagic substrate, p62 and LC3 co-localise with FUS-positive inclusions in sporadic ALS patients,20 linking RNA metabolism and polyubiquitinated protein aggregates to autophagy. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.