Similarly, Rab1 can rescue autophagy impairment induced by α-synuclein in Parkinson’s disease.22 It is therefore probable that mFUS antagonises Rab1-dependent formation of the autophagosome during autophagy.21 Autophagosome traffic on microtubules, and the Rab1 yeast homologue, Ypt1, mediates microtubule organisation and function.44 Hence, the overexpression of Rab1 may restore autophagy and fusion of the autophagosome to the lysosome by mediating microtubule function. This evidence concerns the gene RAB1A and Parkinson disease.