RAB1A and amyotrophic lateral sclerosis: Rab1 proteins mediate all intracellular membrane trafficking events, including ER-Golgi trafficking and autophagosome formation.21–23 Increasing evidence now links ER-Golgi transport to autophagy,21,24,25 and we previously demonstrated that mFUS triggers ER stress in ALS.26 Here, we investigated whether mFUS inhibits autophagy, given the link to the ER.