In addition, U87-EGFRvIII cells express constitutively active epidermal growth factor receptor variant III (EGFRvIII), a mutation found in 30% of glioblastomas and associated with poor patients survival.20 CMPD1 potently reduced viability of glioblastoma cells with EC50 ranging between 0.6 and 1.2 μM (Figure 1a). The gene discussed is SOX9; the disease is glioblastoma.