To determine whether p38 signaling pathway had a central role in the increase in cell apoptosis induced by SFN and Mabs infection, THP-1-derived macrophages were pretreated with MAPK inhibitors of p38, JNK, and ERK, before pretreatment with SFN and Mabs infection, and annexin V-FITC labeling was performed. The gene discussed is MAPK8; the disease is infection.