CASP8 and cancer: The mechanisms underlying curcumin-induced cancer cell death have not been clearly defined, although available evidence suggests that curcumin downregulates NF-κB signaling, which suppresses proliferation and induces apoptosis.8,9 Although both caspase 8-mediated and/or caspase 9-dependent apoptosis have been reported to occur upon the exposure of cancer cells to curcumin,10,11 discrepant results exist for caspase-8.12 Indeed, it is still unclear which caspase functions as the initiator caspase.