RT enhances the expression of tumor-associated antigens and secret immuno-activating danger signals, such as high-mobility group protein B1, heat-shock proteins, calreticulin, ATPs, and hepatoma-derived growth factor; thus, tumors can be easily detected by the immune system.32 Given our previous findings that SNCG was increased and released by irradiated breast cancer cells, we considered the possibility of SNCG as a DAMP, and thus investigated the effect of SNCG on the phenotypical and functional alteration of murine DCs. This evidence concerns the gene HMGB1 and breast carcinoma.