Moreover, Zeb1 impairs the expression of miR-200a, a microRNA targeting the 3ʹUTR GM3S mRNA.4 Overexpressing Twist or Snail in HMLER cells enhances the expression of GD3S.5 Moreover, NF-κB-dependent FOXC2 activation triggers GD3S expression in both human triple-negative breast cancer (TNBC) MDA-MB-231 and Snail-overexpressing HMLER cells.7 Here, ST8SIA1 is linked to triple-negative breast carcinoma.