JAK3 and tongue cancer: In another cohort of patients from Singapore with tongue cancer (primarily Chinese but also Indian and Malay), NOTCH1 mutations occurred infrequently but alterations in other NOTCH pathway genes (i.e. AR, ARNT, EP300, CREBBP, JAK2, JAK3, NCOA1, NOTCH2, NOTCH3, and PARP1) were common (19/60, 32%) and correlated with disease survival [17].