CDKN2A and head and neck squamous cell carcinoma: When compared to white American HNSCC TCGA patients, Indian patients display significantly lower rates of EGFR (p = 0.0365) and MYC (p = 0.0365) amplification, PIK3CA activation by mutation or amplification (p = 0.0027) and CDKN2A deletion (p = 0.0045) (Figure 3).