NOTCH1 and head and neck squamous cell carcinoma: These have demonstrated that 22/51 (43.1%) Chinese oral cavity HNSCC tumors harbored NOTCH1 alterations, with at least half predicted to activate function [109], while only 8/84 (9.5%) Japanese oral cavity HNSCCs had mutations that were all predicted to inactivate NOTCH1 activity [110].