For example, 31/60 (52%) Singaporean patients with tongue cancer displayed mutations in the EGFR pathway (ADCY8, AKT3, COL1A1, COL1A2, EPN1, FGFR3, FGFR4, HRAS, HSP90AA1, IGF1R, ITGAV, ITGB3, JAK2, JAK3, MTOR, PDGFRA, PIK3CD, PIK3CG, PTEN, RASA1, SIPA1, and PIK3CA), and 46/208 (22.1%) of the TCGA cohort displayed amplification of EGFR family members (EGFR, ERBB2-4, EGF, NRG1-4, EREG, AREG, TFGA, BTC, and HBEGF) [1, 17]. The gene discussed is EGFR; the disease is tongue cancer.