JAK3 and tongue cancer: For example, 31/60 (52%) Singaporean patients with tongue cancer displayed mutations in the EGFR pathway (ADCY8, AKT3, COL1A1, COL1A2, EPN1, FGFR3, FGFR4, HRAS, HSP90AA1, IGF1R, ITGAV, ITGB3, JAK2, JAK3, MTOR, PDGFRA, PIK3CD, PIK3CG, PTEN, RASA1, SIPA1, and PIK3CA), and 46/208 (22.1%) of the TCGA cohort displayed amplification of EGFR family members (EGFR, ERBB2-4, EGF, NRG1-4, EREG, AREG, TFGA, BTC, and HBEGF) [1, 17].