For example, 31/60 (52%) Singaporean patients with tongue cancer displayed mutations in the EGFR pathway (ADCY8, AKT3, COL1A1, COL1A2, EPN1, FGFR3, FGFR4, HRAS, HSP90AA1, IGF1R, ITGAV, ITGB3, JAK2, JAK3, MTOR, PDGFRA, PIK3CD, PIK3CG, PTEN, RASA1, SIPA1, and PIK3CA), and 46/208 (22.1%) of the TCGA cohort displayed amplification of EGFR family members (EGFR, ERBB2-4, EGF, NRG1-4, EREG, AREG, TFGA, BTC, and HBEGF) [1, 17]. This evidence concerns the gene JAK2 and tongue cancer.