EFA-CLA increased expression of TSC2 and PTEN tumor suppressors as well as decreased the expression of oncogenes including NOTCH1, AGPS, GNA12, STAT3, UCP2, HIGD2A, HIF1A, and PPKAR1A. The observed results are most likely achieved by the combined effect of both incorporated CLA isomers and other fatty acids in eggs organically modified through hens’ diet. Here, HIF1A is linked to neoplasm.