HMGCR and Familial prostate cancer: In prostate cancer cells, miR-185 and miR-342 control lipogenesis and cholesterol synthesis by down-modulating the expression of sterol regulatory element binding protein 1 and 2 (SREBP-1, SREBP-2), repressing their responsive genes, including fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR; Li X. et al., 2013).