TP53 and cancer: Cancer cells reprogram their metabolism, based on complex regulatory networks involving diverse oncogenic and tumor suppressor genes, including PI3K/Akt, Myc, hypoxia inducible factor (HIF), Ras, Src, p53, and PTEN that promote an increase glucose uptake and glycolysis (Dang et al., 2009; Luo and Semenza, 2011).