Interestingly, ANRIL regulates genes involved in glucose and fatty acid metabolism (Bochenek et al., 2013), such as ADIPOR1. Furthermore, ANRIL can epigenetically regulate the expression of miRNAs in gastric cancer cells, particularly miR-99a/miR-449a, which target CDK6/E2F1 and mTOR pathways (Zhang et al., 2014), that regulate lipid metabolism and adipose tissue function (Cai et al., 2015). This evidence concerns the gene CDKN2B-AS1 and gastric cancer.