Likewise, overexpression of miR-125b in lymphocytic leukemia models represses many transcripts implicated in energetic and lipid metabolism including phosphatidylcholine transfer protein, lipase A, lysosomal acid, cholesterol esterase, glutathione synthetase, acyl-CoA synthetase short-chain family member 1, HK2, stearoyl-CoA desaturase 1, AKT2, and pyruvate dehydrogenase kinase 1 (PDK1; Tili et al., 2012). The gene discussed is PDK1; the disease is lymphoid leukemia.