Recently, Keeshan et al. 11 showed that Trib2 regulates the fate of myeloid precursor cells by modulating the level of the critical myeloid differentiation transcriptional factor, C/ebpα, and found that ectopic Trib2 overexpression in myeloid progenitors resulted in development of acute myeloid leukemia in mice12. This evidence concerns the gene TRIB2 and acute myeloid leukemia.