We observed that both the frequency and number of inflammatory monocytes (identified as CD45+CD11b+Ly-6ChiCCR2hi) were markedly reduced in the blood, spleen and liver of Pxr−/− mice at 24 hours post infection even when the bacterial burden was comparable between Pxr−/− and WT mice (Fig. 4). This evidence concerns the gene PTPRC and infection.