Moreover, although blockade RANKL by monoclonal anti-RANKL antibody Denosumab could efficiently prevent bone loss in resorptive diseases such as RA and osteoporosis, but also could cause rare but significant, clinical complications such as osteonecrosis of the jaw and atypical subtrochanteric femoral fractures6, which might due to profound inhibition of RANKL and subsequently affecting bone turnover. The gene discussed is TNFSF11; the disease is osteoporosis.