In the randomized, double‐blind, placebo‐controlled CANVAS study, patients failing treatment for diabetes with an incretin mimetic (dipeptidyl peptidase‐4 inhibitor or GLP‐1RA) received the SGLT2 inhibitor canagliflozin or placebo.29 After 18 weeks, placebo‐subtracted reductions in body weight were −2.7 and −3.3 kg with canagliflozin 100 and 300 mg, respectively, both added to a GLP‐1RA. Here, SLC5A2 is linked to diabetes mellitus.