The best EMT-associated miRNA/mRNA signature for the prediction of 5-year overall survival, consisting of 5 candidate miRNAs (miR-200a, miR-200b, miR-200c, miR30a-3p, miR429) and 3 candidate genes (C3orf52, CDH1, PAPSS2), allowed accurate prediction of outcome of more than 70% of ccRCC patients. Here, C3orf52 is linked to nonpapillary renal cell carcinoma.