There are no significant differences in the gender, patients of benign: malignant, and body mass index (BMI) of patients between RAPN and OPN, but the age was lower (WMD, −1.52 years; 95 % CI, −2.53 to −0.51; p = 0.003) and the tumor size was smaller for RAPN group (WMD, −0.46 cm; 95 % CI, −0.66 to −0.26; p < 0.01). Here, SPP1 is linked to neoplasm.